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Man exercising - Copyright: Corbis Injecting drug user - Copyright: Photolibrary Home birth - Copyright: Photolibrary
Article
Review
Editorial
Statin therapy and cardiovascular events: analysis of the JUPITER trial cohort addresses whether HDL cholesterol concentrations are predictive of cardiovascular risk at low concentrations of LDL cholesterol. HIV in people who use drugs: prevalence and frequency of medical, psychiatric, and substance-use disorders. Home birth: women are advised to proceed with caution when deciding to give birth outside hospital setting.
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Journal cover

Editorial

347
The perils of journal and supplement publishing
The Lancet
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348
Should protocols for observational research be registered?
The Lancet
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348
Complicity in the abuse of patients
The Lancet
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Comment

349
Challenging the dogma on trastuzumab: a matter of the heart
Melanie D Seal, Stephen K Chia
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350
A new BALANCE in bipolar I disorder
Rasmus W Licht
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352
Switching HIV therapies: competing host and viral factors
J Michael Kilby
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354
Reforming country health systems for women's health
Badara Samb
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355
Rajiv Shah at USAID: reviving nutrition for the world's poor
Keith P West, Robert E Black
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357
A flexible blueprint for the future of drug development
Richard Barker
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359
Vote online for paper of the year 2009
William Summerskill
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360
Offline: The rational irrationality of fear
Richard Horton
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World Report

361
Comparative effectiveness research stalls in the USA
Paul Christopher Webster
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363
India failing children orphaned by AIDS
Bharathi Ghanashyam
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Perspectives

365
The biology and politics of obesity
Nicholas Freudenberg
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366
Living, breathing history
Elizabeth Leyland
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367
The swine flu backlash
Jeremy Laurance
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367
Luca Gianni
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368
Autonomy should chair, not rule
Charles Foster
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Obituary

370
Jeremy Noah Morris
Geoff Watts
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Correspondence

371
Did mass privatisation really increase post-communist mortality?
Christopher J Gerry, Tomasz M Mickiewicz, Zlatko Nikoloski
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372
Did mass privatisation really increase post-communist mortality?
John S Earle, Scott Gehlbach
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372
Did mass privatisation really increase post-communist mortality? – Authors' reply
David Stuckler, Lawrence King, Martin McKee
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374
Addressing congenital causes of disability
Luis Nacul, Sowmiya Moorthie, Mukesh Kapila, Ron Zimmern
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375
Human resources for health: focusing on people with disabilities
Hasheem Mannan, Malcolm MacLachlan
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375
HORIZONS-AMI
Mark WI Webster
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376
Migrants and the right to health: the students' perspective
Robbert Duvivier, Mori Mansouri, Diego Iemmi, Silva Rukavina
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376
Clinical academics should and must teach
Jonathan TL Cheah
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Department of Error

376
Department of Error
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Articles

377
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort
Luca Gianni, Wolfgang Eiermann, Vladimir Semiglazov, Alexey Manikhas, Ana Lluch, Sergey Tjulandin, Milvia Zambetti, Federico Vazquez, Mikhail Byakhow, Mikhail Lichinitser, Miguel Angel Climent, Eva Ciruelos, Belén Ojeda, Mauro Mansutti, Alla Bozhok, Roberta Baronio, Andrea Feyereislova, Claire Barton, Pinuccia Valagussa, Jose Baselga
Summary | Full Text | PDF
385
Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
The BALANCE investigators and collaborators
Summary | Full Text | PDF
396
Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomised controlled trials
Joseph J Eron, Benjamin Young, David A Cooper, Michael Youle, Edwin DeJesus, Jaime Andrade-Villanueva, Cassy Workman, Roberto Zajdenverg, Gerd Fätkenheuer, Daniel S Berger, Princy N Kumar, Anthony J Rodgers, Melissa A Shaughnessy, Monica L Walker, Richard JO Barnard, Michael D Miller, Mark J DiNubile, Bach-Yen Nguyen, Randi Leavitt, Xia Xu, Peter Sklar, for the SWITCHMRK 1 and 2 investigators
Summary | Full Text | PDF

Seminar

408
Diabetes in Asia
Ambady Ramachandran, Ronald Ching Wan Ma, Chamukuttan Snehalatha
Summary | Full Text | PDF

Health Policy

419
Financing of health systems to achieve the health Millennium Development Goals in low-income countries
Robert Fryatt, Anne Mills, Anders Nordstrom
Summary | Full Text | PDF

Viewpoint

427
A framework for mandatory impact evaluation to ensure well informed public policy decisions
Andrew D Oxman, Arild Bjørndal, Francisco Becerra-Posada, Mark Gibson, Miguel Angel Gonzalez Block, Andy Haines, Maimunah Hamid, Carmen Hooker Odom, Haichao Lei, Ben Levin, Mark W Lipsey, Julia H Littell, Hassan Mshinda, Pierre Ongolo-Zogo, Tikki Pang, Nelson Sewankambo, Francisco Songane, Haluk Soydan, Carole Torgerson, David Weisburd, Judith Whitworth, Suwit Wibulpolprasert
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Case Report

432
What lurks in the sellar?
Sandra Pekic, Valentina Arsic Arsenijevic, Milica Skender Gazibara, Toplica Milojevic, Ivica Pendjer, Marko Stojanovic, Vera Popovic
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