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Alteplase 3-4·5 h after stroke: in an updated analysis from the SITS-ISTR registry, researchers investigate whether the extended time window for alteplase treatment has led to prolonged admission-to-treatment times. Spinocerebellar ataxias: clinical features and pathophysiological mechanisms of autosomal dominant forms. Alzheimer's disease: new research strategies to speed up evaluation of preventive treatments in people at risk.
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Leading Edge

373
The trials and tribulations of Tysabri
The Lancet Neurology
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Reflection and Reaction

374
Of mice and men … and vCJD
Corinne Ida Lasmézas
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375
The return of natalizumab: weighing benefit against risk
Douglas Goodin
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377
Good clinical practice in neurorehabilitation
Volker Dietz
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379
Anticholinergic drugs and elderly people: a no brainer?
P Murali Doraiswamy, Mustafa M Husain
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380
Treatment of drug resistance in epilepsy: one step at a time
Sanjay M Sisodiya, Susan E Bates
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382
Assisted living at the end of life
CL Kraaijeveld
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382
To the point: acupuncture and migraine
Stephen L Black
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383
To the point: acupuncture and migraine – Author's response
HC Diener
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383
Submit online to The Lancet Neurology
Rebecca Love, Mark Harrington
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Errata

383
Errata
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383
Errata
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Newsdesk

384
News in brief
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386
Nano neuro knitting repairs injured brain
Laura Thomas
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386
Atorvastatin and glatiramer acetate: new hope in MS?
Jane Bradbury
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387
Social life best prescription for mental stress?
Elena Becker-Barroso
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388
Boosting brain endocannabinoids in multiple sclerosis
Helen Frankish
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388
Alzheimer's disease could be “type 3 diabetes”
Helen Pilcher
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389
African meningitis belt: 2006
Peter Hayward
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390
UK Biobank launched to mixed reception
Kathryn Senior
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Media Watch

391
Pure genius
James Butcher
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392
Neurological artform
Graeme J Hankey
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392
Sisterly devotion to medical research
Peter Hayward
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Articles

393
Predicting susceptibility and incubation time of human-to-human transmission of vCJD
MT Bishop, P Hart, L Aitchison, HN Baybutt, C Plinston, V Thomson, NL Tuzi, MW Head, JW Ironside, RG Will, JC Manson
Summary | Full Text | PDF
399
Rapid detection of major depression in epilepsy: a multicentre study
Frank G Gilliam, John J Barry, Bruce P Hermann, Kimford J Meador, Victoria Vahle, Andres M Kanner
Summary | Full Text | PDF
406
The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study
David A Bennett, Julie A Schneider, Yuxiao Tang, Steven E Arnold, Robert S Wilson
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Review

413
Vanishing white matter disease
Marjo S van der Knaap, Jan C Pronk, Gert C Scheper
Summary | Full Text | PDF
424
Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases
Jean-François Gagnon, Ronald B Postuma, Stéphanie Mazza, Julien Doyon, Jacques Montplaisir
Summary | Full Text | PDF
433
Idiopathic intracranial hypertension
Alex K Ball, Carl E Clarke
Summary | Full Text | PDF
443
Neoplastic meningitis
Beate Gleissner, Marc Charles Chamberlain
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Personal View

453
Olfactory ensheathing cells: ripples of an incoming tide?
Ahmed Ibrahim, Ying Li, Daqing Li, Geoffrey Raisman, Wagih S El Masry
Summary | Full Text | PDF

Grand Round

458
Headache and vision loss in a 41-year-old man
Raed Behbehani, Salim Al-Mutairi
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